Administration of tetracycline in pregnancy can deposit it into fetal bones that can stun fetal growth. Administration of this drug to children also can stun their growth. Pigmentation of permanent teeth can also occur. At first maximum of drugs binds with plasma protein then deposited in an unbound form in the tissues. Can also lead to type 2 diabetes. Which is not good at pregnancy. In this article, we will talk about relationship problems while pregnant and solutions because of tetracycline in pregnancy.
1. Absorption: Stomach, duodenum, small intestine
2. Half-life: 6-8 Hours
3. Best Administration site: Oral
4. Excretion: Biliary Tract
5. Deposition: Bone marrow, Reticuloendothelial cells of liver, Spleen, Teeth
Mechanism of Action(MOA):
3 mechanisms: CHELATION; INHIBITION OF PROTEIN SYNTHESIS; INHIBITION OF ESSENTIAL ENZYMES
1. Chelation: Can bind with Magnesium, Manganese, Calcium. Also, tetracycline can inhibit oxidative phosphorylation in mitochondria but this is overcome for Magnesium.
2. Inhibition of protein synthesis:[IPS] Tetracycline can inhibit protein synthesis but can not inhibit nucleic acid. Some authors recommended that tetracycline may effect on ribosomes.
3. Inhibition of essential enzymes:[IEE] Tetracycline can inhibit enzymes such as “Nitro-reductase”. Manganese do this reduction due to the capacity of chelate essential metals.
Can tetracycline in pregnancy cause learning or behavioral problems in the child?
A baby’s brain continues to develop right up until the end of pregnancy. It is therefore possible that taking certain medicines at any stage of pregnancy could have a lasting effect on a child’s learning or behavior.
No link with learning and behavioral problems (e.g. autism spectrum disorder [ASD] and attention deficit hyperactivity disorder [ADHD]) is known about in children who were exposed to tetracycline while in the womb, however, no studies have been carried out to specifically investigate this.